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Anti-Aging Benefits Diminishes wrinkles, fine lines, and sagging, making skin look younger and firmer
In ovaries, it seems that CSE must be silenced upon malignant transformation, since it is expressed in normal epithelial ovarian cells but it is absent in malignant tumors ( 2 S production, which activates cancer cells proliferation and migration, through ROS/PI3K/AKT/mTOR and MAPK pathways ( Cysteine degradation catalyzed by CAT and MST (Figure 1B) is not deeply explored in cancer, since MST is more enzymatically efficient at a pH higher than the physiological, thus the role of CBS and CSE is considered more relevant in cancer biology ( 2 S from N-acetylcysteine instead of cysteine-derived 3-mercaptopyruvate
Wisniewski, J
Mechanism mapping (Nature Communications, 2025) Identified the disordered p53 transactivation domain as the binding target, adding structural detail to the mechanism
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